Imo state university teaching hospital imsuth orlu 2018, it was recorded that about 328 new cases of breast cancer were diagnosed between 2014 to 2016 and from 2016 to 2018, 98 new cases were diagnosed with about 10 deaths occurring within this. There is a large variation in breast cancer survival rates around the world, with an. Breast cancer risk from modifiable and nonmodifiable risk. As a consequence of responding to colleagues who asked about the publication of the original article 1, the authors have determined that the data published in table 4 of the paper are incorrect. Prevalence of pathogenic variants in cancer susceptibility. Here, we evaluated whether obesity is differentially associated with the risk of breast tumor subtypes, as defined by 6 immunohistochemical markers er, pr, her2, ki67, bcl2 and p53. Breast cancer is a type of cancer that starts in the breast. Breast cancer is the most common cancer and also the leading cause of cancer mortality in women worldwide. Breast cancer wellness magazine winter 2020 featured. A family history of breast cancer and other factors increase the risk of breast cancer. May 31, 2018 earlier epidemiological studies indicate that associations between obesity and breast cancer risk may not only depend on menopausal status and use of exogenous hormones, but might also differ by tumor subtype. Top 10 breast cancer articles of 2016 breast cancer news. Jan 06, 2020 in the united states, an estimated 15. For the management of abnormal cervical screening tests and cancer precursors.
Article transcriptomic response of breast cancer cells mda. Jan 04, 2017 a number of important discoveries, therapeutic developments, and events related to breast cancer were reported daily by breast cancer news. Breast cancer is the most frequent malignancy in women worldwide and is curable in 7080% of patients with earlystage, nonmetastatic disease. According to the globocan database,1 an estimated 94 378 new cases of breast cancer are diagnosed in subsaharan africa annually.
In 2016, mortality from breast cancer in the eu is expected to drop by 8%. California breast cancer research program, university of california. About breast cancer national breast cancer foundation. Declines in breast cancer mortality could be accelerated by expanding access to high. Pdf clinical diagnosis and management of breast cancer. Breast cancer affects one in eight women during their lives. Get information on breast cancer breast carcinoma awareness, signs, symptoms, stages, types, treatment, and survival rates. Pathogenesis, prevention, diagnosis and treatment of. Table of contents international journal of breast cancer. In 2004, breast cancer caused 519,000 deaths worldwide 7% of cancer deaths.
Research article open access nilco biomarkers in breast. This open access article is distributed under a creative commons attribution. The 10 cancerspecific papers in the supplement provide the percentage of people who live for at least five years after being told they have cancer. Citescore values are based on citation counts in a given year e. Cdcs division of cancer prevention and control led a special issue in the journal cancer about cancer survival in the united states. Pdf on jun 1, 2014, ahmed elsharkawy and others published breast cancer find, read and cite all the research you need on.
Research includes molecular pathology, genomics, genetic predisposition etc. Breast cancer articles cancer death rates continue to decline cancer deaths in the united states are continuing to decline, but there was a slight increase in the number of new cancers in women between 2012 and 2016. Each issue contains several articles dealing with original laboratory investigations and articles dealing with clinical studies. Learn what breast cancer is and about symptoms, risk factors, mammograms, diagnosis, and treatment for breast cancer. Since last two decades, researches related to the breast cancer has lead to extraordinary progress in our understanding of the disease, resulting in more efficient and less toxic treatments. Breast cancer research is the highest ranking breast cancerspecific title in the top quartile of oncology journals worldwide.
Mri magnetic resonance imaging, ultrasound, and clinical breast exams are also used to detect breast cancer, but not as routine screening tools ongoing studies are looking at ways to enhance current breast cancer screening options. Aug 12, 2019 breast cancer survival rates are rising as screening and treatment improve. Any breast lump or change needs to be checked by a health care professional to determine if it is benign or malignant cancer and if it might affect your future cancer risk. Breast cancer research and treatment aims to fill this need. Breast cancer research articles national cancer institute. Breast cancer is the second most common cancer among women in the united states. Breast cancer wellness magazine offers great stories of inspiration, informative articles on treatment, many different avenues for help and support. Incidence rates vary considerably between african countrieseg, 38 new cases per 100 000 women per year in kenya compared with 28 cases per 100 000 women per year in uganda.
Breast cancer is sometimes caused by inherited gene mutations changes. Breast cancer is the most common nonskin cancer of american women, but it can also occur in men. Breast cancer is a disease in which malignant cancer cells form in the tissues of the breast. Despite increasing developments in therapeutic strategies, breast cancer remains a deadly threat to patients 2.
The original article was published in breast cancer research 2014 16. Apr 23, 2020 international journal of breast cancer provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The paradoxical functions of egfr during breast cancer. Risk factors and preventions of breast cancer ncbi. A quantitative study to assess breast cancer awareness.
Treating breast cancer learn about your choices for breast cancer treatment depending on the type, stage, and hormone status of the cancer, as well as your age, overall health, and personal preferences. Global status of advanced metastatic breast cancer. A study suggests that women age 50 and older who lost weight and kept it off have a lower risk of breast cancer than women whose weight remained the same. Having dense breast tissue can increase your risk for breast cancer and make lumps harder to detect. Get the information you need to understand your breast cancer diagnosis with details on the various types of breast cancer, grading, hormone status, staging, and prognosis. The study, which included patients with erpositive, lymph nodenegative. Like most advanced cancers, metastatic breast cancer mbc is incurable. It was reported that the estimates of new breast cancer cases were about 278 900 and the estimates of breast cancer deaths were 66 000 in china in 2014 for female. The division of cancer prevention dcp conducts and supports research to determine a persons risk of cancer and to find ways to reduce the risk. Sep 23, 2019 breast cancer is the most frequent malignancy in women worldwide and is curable in 7080% of patients with earlystage, nonmetastatic disease. Research article open access nilco biomarkers in breast cancer from chinese patients laronna s colbert1,2, kaamilah wilson3, sungjin kim4,yuanliu4,gabrielaopreailies5, corey gillespie3,toidickson3, gale newman3 and ruben rene gonzalezperez3 abstract background. Jan 20, 2017 the epidermal growth factor receptor egfr is one of the most wellstudied signaling pathways in cancer progression.
Article pdf available in world journal of pharmacy and. The molecular mechanisms underlying the association between increased. Breast cancer is the most frequent malignant tumor in women and accounts for about 25% of all carcinomas diagnosed in women worldwide 1,2. Therapeutic approaches for breast cancer have changed over the past few decades, and the use of systemic therapy for early and advanced disease tailored to the individual patient holds the promise of delivering treatment to those in need and who could benefit the most. No one knows why some women get breast cancer, but there are many risk factors. The first pair of papers focus on the treatment of advanced oestrogenreceptor positive and her2positive breast cancers, while the third. Notch, il1 and leptin are known proangiogenic factors linked to breast cancer development, tumor. Here are the top 10 mostread articles of 2016, with a brief description of what made them interesting and relevant to breast cancer patients, family members, and caregivers. Supporting the use of pet to evaluate advanced breast cancer, a metaanalysis of 5 studies 547 patients demonstrated a sensitivity for breast cancer of 0. The jbcs editorial committee has selected the following as the most influential articles from breast cancer. In the nurses health study followup, women with a mother diagnosed before age 50 had an adjusted relative risk of 1. Cdcs national breast and cervical cancer early detection program provides lowcost.
Breast cancer is the most common cancer and also the primary cause of mortality due to cancer in female around the world. Breast cancer was the leading cause of cancer death in women surpassing lung cancer in four southern and two midwestern states among blacks and in utah among whites during 2016. Pathogenesis, prevention, diagnosis and treatment of breast. Learn about the various risk factors, both genetic and lifestylerelated, as well as prevention methods for breast cancer from the american cancer society. Get basic information about breast cancer, such as what it is and how it forms, as well as the signs and symptoms of the disease. Nutrition influences cancer etiology in about 35% of cancer cases. Open access research articles of exceptional interest are published in all areas of biology and medicine relevant to breast cancer, including normal mammary gland biology, with special emphasis on the genetic, biochemical, and cellular basis of breast cancer. However, breast cancer is still the most invasive cancer in women. Its important to have any breast change checked by a health care provider. Advances in breast cancer research national cancer institute. Several states have passed laws requiring physicians to disclose to women if their mammogram indicates that they have dense breasts so that they are aware of this risk. As a result, numerous therapeutics including smallmolecule inhibitors and. One example of this is the ncisponsored tailorx clinical trial.
A womans risk of breast cancer is increased if she has a family history of the disease. In recent years there has been a lot of research in the field of breast cancer. It is the largest study ever to investigate how genetic and biological factors contribute to breast cancer risk among black women. Pdf breast cancer is the second leading cause of cancer deaths among women. Abstract background previous trials showed promising antitumor activity and an acceptable safety profile associated with pembrolizumab in patients with early triplenegative breast cancer. As we learn more about the subtypes of breast cancer and their behavior, we can use this information to guide treatment decisions. Breast cancer a guide for journalists on breast cancer and. Acs breast cancer screening guideline cdc guideline for prescribing opioids cdc guideline for prevention of surgical site infections consensus definitions for sepsis and septic shock global burden of cancer, 1990 2016 global burden of disease in children, 199020 global burden of hypertension, 19902015 global firearm mortality, 1990 2016. Genes two genes, brca1 and brca2, greatly increase the risk. Breast cancers found by yearly mammograms smaller, less advanced than cancers found by mammograms every 2 years. An expanded agenda for the primary prevention of breast cancer. Pdf risk factors and preventions of breast cancer researchgate. Most downloaded clinical breast cancer articles elsevier.
The use of certain medicines and other factors decrease the risk of breast cancer. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer. Breast cancer is one of a few cancers for which an effective screening test, mammography, is available. Breast cancer signs and symptoms what is breast cancer. Find, read and cite all the research you need on researchgate. Dec 06, 2016 the lancet s 2016 series on breast cancer discusses the most recent advances in the three most common breast cancer subtypes. Pembrolizumab for early triplenegative breast cancer nejm. Read about different tests, prevention and early signs.
The first pair of papers focus on the treatment of advanced oestrogenreceptorpositive and her2positive breast cancers, while the third describes how an improved understanding of molecular alterations in the. Preventive dietary advice often includes reducing intake of alcohol, red meat, and fat and increasing intake of fiber and vitamin d as well as phytoestrogens from various food sources. Recent advances in the medical treatment of breast cancer. The authors declared that this study has received no financial support. Now days, breast cancer is the most frequently diagnosed lifethreatening cancer in women and the leading cause of cancer death among women. The breast cancer genetic study in africanancestry populations initiative is a collaborative research project that will identify genetic factors that may underlie breast cancer disparities. The most downloaded articles from clinical breast cancer in the last 90 days. Obesity as risk factor for subtypes of breast cancer. Breast cancer is a growing problem in lowresource settings.